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2 edition of In vitro granulopoietic studies found in the catalog.

In vitro granulopoietic studies

Alexandra Elizabeth Irvine

In vitro granulopoietic studies

investigation of a putative neutrophil stimulating activity.

by Alexandra Elizabeth Irvine

  • 232 Want to read
  • 26 Currently reading

Published .
Written in English


Edition Notes

Thesis (Ph. D.)--The Queen"s University of Belfast, 1983.

The Physical Object
Pagination1 v
ID Numbers
Open LibraryOL21034727M

  The proliferative potential following in vitro irradiation of bone marrow fibroblastic progenitors (CFU-F) derived from four patients with acute nonly. In vitro (meaning: in the glass) studies are performed with microorganisms, cells, or biological molecules outside their normal biological context. Colloquially called "test-tube experiments", these studies in biology and its subdisciplines are traditionally done in labware such as test tubes, flasks, Petri dishes, and microtiter s conducted using components of an .

Starting at the molecular level of studies, continuing with cell monolayer models (both primary and cell lines) and in situ techniques as a final testing format, the book provides a practical. There are three broad categories of experiments: in vitro A technique of performing a given procedure in a controlled environment outside of a living organism - usually a laboratory. studies, in vivo A type of scientific study that analyzes an organism in its natural living environment. studies, and in silico Experiment technique performed on computer or via computer emulation. studies.

Studies with human cells have reported both increased CSA production by peripheral blood leukocytes (Joyce and Chervenick, ) and an adjuvant effect on granulopoietic precursor cells (in vitro colony forming cells, CFU-C) (Morley and Galbraith, ). In Vivo and In Vitro Studies in Experimental Model Systems Studies performed using in vivo and in vitro (animal and cellular) experimental model systems are critical components of the effort to iden- tify adverse health effects of exposure to radiofrequency (RF) fields gen- erated by wireless communications devices.


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In vitro granulopoietic studies by Alexandra Elizabeth Irvine Download PDF EPUB FB2

T lymphocytes can mediate granulopoietic failure in a variety of conditions, and in vitro studies identify most of the patients with these conditions. Hemopoietic inhibitory T cells are often steroid-sensitive, and in vitro study accurately predicts responses to steroid therapy.

(N Engl J Med ;–8.).Cited by: In vitro studies of the granulopoiesis committed stem cell pool in haematologically normal subjects Author links open overlay panel D.E.

Lind P.C. Vincent F.W. Gunz Show moreAuthor: D.E. Lind, P.C. Vincent, F.W. Gunz. In Vitro Modulation of Human Erythropoiesis by Lymphocyte-Rich Fractions of Blood.- 4. Cryogenic Preservation of Human and Murine Erythropoietic and Granulopoietic Colony-Forming Cells.- 5.

Miniaturization of Methylcellulose Erythroid Colony Assay.- 6. Culture Systems In Vitro for the Assay of Erythrocytic and Megakaryocytic Progenitors   Leukemia Research Vol. 11, No. 5, pp./87 $ + Printed in Great Britain. Pergamon Journals Ltd.

IN-VITRO GRANULOPOIESIS IN ADULT ACUTE LYMPHOBLASTIC LEUKEMIA AT VARIOUS PHASES OF THE DISEASE LEE-YUNG SHIH and WEN-FUNG CHIU Division of Hematology, Department of Internal Medicine, Chang Cited by: 4. Stem cells committed to granulopoiesis in the mouse can be assayed by an in-vitro method in which colonies are grown from marrow cells plated in soft agar tissue cultures.

The number of these colonies in the mouse has been shown to measure the number of granulopoietic stem cells present. Studies of this type allow, for the first time Author: D.E. Lind, P.C. Vincent, F.W. Gunz. Steed AJ, Pylypczuk R, Routledge RC, Delamore IW. The formation of colonies by normal human bone marrow granulopoietic progenitor cells in vitro in soft agar was inhibited in a simple, dose-dependent manner by amiloride (50% inhibitory concentration +/- microM, n = 9).

Int J Radiat Biol Relat Stud Phys Chem Med. Feb;43(2) In vitro studies on the sensitivity of canine granulopoietic progenitor cells (GM-CFC) to ionizing radiation: differences between steady state GM-CFC from blood and bone marrow.

In order to analyze this phenomenon, in vitro agar culture studies were carried out. A three- to fourfold increase of colony-forming units in culture was observed in the femurs Demonstration of Granulopoietic Factor(s) in the Plasma of Nude Mice Transplanted With a Human Lung Cancer and in the Tumor Tissue.

In Vitro Toxicology details the protocols and methods of in vitro testing, highlighting the usefulness of models, methods and the cost-effectiveness and reproducibility of such current approaches and strategies required to develop an easy, reliable, validated and high throughput system for use in alternative animal models to circumvent in.

The In Vivo Granulopoietic Response to Dexamethasone Injection Is Abolished in Perforin-Deficient Mutant Mice and Corrected by Lymphocyte Transfer from Nonsensitized Wild-Type Donors Pedro Xavier-Elsas, 1, * Cássio Luiz Coutinho Almeida da Silva, 1 Bruno Marques Vieira, 2 Daniela Masid-de-Brito, 1 Túlio Queto, 2 Bianca de Luca, 2.

In vitro granulopoietic studies: Investigation of a putative neutrophil stimulating activity Author: Irvine, A. ISNI: X Awarding Body: Queen's University Current Institution: Queen's University Belfast Date of Award: Modulation of murine in vitro erythroid and granulopoietic colony formation by ouabain, digoxin and theophylline.

Gallicchio VS, Chen MG, Murphy MJ Jr. Ouabain has been shown to increase the number of clonally derived erythroid stem cells.

Skin cells in in vitro cultures are used to also assess impact of stress factors (e.g. UV or free radicals) on cells structure. In vitro tests include studies of cosmetics materials’ cytotoxicity, evaluation of the level of synthesis and cell activity of enzymatic proteins, effects of growth agents and various types of compounds ultimately.

Bradley TR, Metcalf D. The growth of mouse bone marrow cells in vitro. Aust J Exp Biol Med Sci. Jun; 44 (3)– Ichikawa Y, Pluznik DH, Sachs L. In vitro control of the development of macrophage and granulocyte colonies.

Proc Natl Acad Sci U S A. Aug; 56 (2)– [PMC free article] Pluznik DH, Sachs L. Editorial from The New England Journal of Medicine — In Vitro Granulopoietic Colonies. In Vitro Bioequivalence (BE) Pathways Marilyn Martinez, Ph.D., Senior Biomedical Research Scientist, Office of New Animal Drug Evaluation, Center for Veterinary Medicine, FDA.

The in vitro studies of marrow colony formation at the time June The American Journal of Medicine Volume 66 GRANULOPOIETIC PARAMETERS IN PRELEUKEMIA-GREENBERG, MARA of diagnosis did not predict subsequent transformation. In the last 15 years, a great number of cell- or tissue-based in vitro models have been introduced into the biopharmaceutics arena.

These models mimic the different biological barriers that a drug has to overcome to finally reach its target organ/cell/receptor. These in vitro models have been found very useful in not only characterising the permeability behaviour of. Lee-Yung Shih, Wen-Fung Chiu, Po Dunn, Shiumn-Jen Liaw, In vitro culture studies of blood and marrow cells in chronic myeloid leukemia at different phases of the disease, Blut, /BF, 57, 3, (), ().

A wide variety of compounds have the capacity to induce granulocytic differentiation of normal and leukaemic granulopoietic precursors in vitro. Despite the therapeutic potential of these agents, little is known about their mechanisms of action. Starting at the molecular level of studies, continuing with cell monolayer models (both primary and cell lines) and in situ techniques as a final testing format, the book provides a practical approach to contemporary in vitro techniques for drug absorption studies.*There are literature reports (compiled in reference 26) showing that, in some studies but not in others, cyclophosphamide can be clastogenic in vitro in the absence of metabolic activation.

If.Phenotypic characterization of myeloid leukemia utilizing in vitro culture methodologies suggests that subtile regulatory imbalance may play a major role in clonal dominance of transformed pluripotential stem cells or committed granulopoietic progenitor cells.